EUMODIC - The European Mouse Disease Clinic: A distributed phenotyping resource for studying human disease (FP6-LIFESCIHEALTH) (2007-02-01 - 2011-01-31) (»add to infobox)

Steve BROWN, Johan AUWERX, Martin HRABE DE ANGELIS, Karen Penelope STEEL, Werner MUELLER, Glauco TOCCHINI-VALENTINI, Ludwig NEYSES, Nadia ROSENTHAL, Mariano BARBACID, Jacqueline MARVEL, Karen AVRAHAM, Marco BREUER, Fatima BOSCH, Walter WAHLI, Yann HÉRAULT, Paul Nicholas SCHOFIELD, Andrea BALLABIO, George KOLLIAS

MEDICAL RESEARCH COUNCIL (UKI11 - Inner London - West) (Great Britain), CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE (FR421 - Bas-Rhin) (France), GSF - FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH (DE21 - Oberbayern) (Germany), GENOME RESEARCH LTD (UKI11 - Inner London - West) (Great Britain), HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH (DE911 - Braunschweig, Kreisfreie Stadt) (Germany), CONSIGLIO NAZIONALE DELLE RICERCHE (ITE43 - Roma) (Italy), THE UNIVERSITY OF MANCHESTER (UKD31 - Greater Manchester South) (Great Britain), EUROPAISCHES LABORATORIUM FUER MOLEKULARBIOLOGIE - EMBL (DE125 - Heidelberg, Stadtkreis) (Germany), FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES300 - Madrid) (Spain), ECOLE NORMALE SUPERIEURE DE LYON (FR716 - Rhône) (France), TEL AVIV UNIVERSITY (ME04 - Israel) (Israel), HET NEDERLANDS KANKER INSTITUUT / ANTONI VAN LEEUWENHOEK HOSPITAL (NL326 - Groot-Amsterdam) (Netherlands), UNIVERSITAT AUTONOMA DE BARCELONA (ES511 - Barcelona) (Spain), UNIVERSITE DE LAUSANNE (CH022 - Freiburg) (Switzerland), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR101 - Paris) (France), THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UKH12 - Cambridgeshire CC) (Great Britain), FONDAZIONE TELETHON (ITE43 - Roma) (Italy), BIOMEDICAL SCIENCES RESEARCH CENTRE "ALEXANDER FLEMING" (GR300 - Attiki) (Greece)

As a first step towards a comprehensive functional annotation of the mouse genome, EUMODIC will undertake a primary phenotype assessment of up to 650 mouse mutant lines. In addition, a number of the mutant lines will be subject to a more in depth secondary phenotype assessment. The EUMODIC consortium is made up of 18 laboratories across Europe who are experts in the field of mouse functional genomics and phenotyping and have a track record of successful collaborative research in EUMORPHIA. The EUMODIC consortium will build on the work in the EUMORPHIA project that delivered a comprehensive database ' EMPReSS - of Standard Operating Procedures (SOPs) that can be used to determine the phenotype of a mouse. EUMODIC has developed a selection of these screens, EMPReSSslim, which is structured for comprehensive, primary, high throughput phenotyping of large numbers of mice. We will also adopt innovative approaches to the generation and assessment of cohorts of age-matched mutants and controls for phenotyping. Primary phenotype assessment using EMPReSSslim will be undertaken in four large-scale phenotyping centres at the GSF, Germany; ICS, France; MRC Harwell, UK and the Sanger Institute, UK. Mutant lines will be made available from another EU initiative, the EUCOMM (European Conditional Mouse Mutagenesis) project which aims to produce conditional mutations in 20,000 mouse genes. A distributed network of centres with in depth expertise in a number of phenotyping domains will undertake more complex, secondary phenotyping screens and apply them to a subset of the mice which have shown interesting phenotypes in the primary screen. The partners will also develop technologies to refine EMPReSSslim and improve throughput of mouse phenotyping. A key element will be the continued development of bioinformatics resources to store the phenotype information and link them to existing database resources.

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