EUCLOCK - Entrainment of the Circadian Clock (FP6-LIFESCIHEALTH) (2006-01-01 - 2010-12-31) (»add to infobox)

Till ROENNEBERG, Urs ALBRECHT, Howard Michael COOPER, Rodolfo COSTA, Dominicus G. M. BEERSMA, Charlotte FÖRSTER, Russell FOSTER, Achim KRAMER, Charalambos Panayiotis KYRIACOU, Johanna H. MEIJER, Thomas MEITINGER, Andres METSPALU, Andrew J. MILLAR, Ferenc NAGY, Patrick Martin NOLAN, Francois ROUYER, Ueli SCHIBLER, Debra Jean SKENE, Alena SUMOVA, Gijsbertus T. J. VAN DER HORST, Anna WIRZ-JUSTICE, Konstantin V. DANILENKO, Patrick HICKEY, Roland KOPPER, Hans-Peter LIPP, Anand KUMAR, Ninoslav MARINA, Thomas M. JERMANN, Ralf STANEWSKY

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (DE212 - München, Kreisfreie Stadt) (Germany), UNIVERSITE DE FRIBOURG (CH021 - Bern) (Switzerland), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR716 - Rhône) (France), UNIVERSITA DEGLI STUDI DI PADOVA (ITD36 - Padova) (Italy), RIJKSUNIVERSITEIT GRONINGEN (NL113 - Overig Groningen) (Netherlands), UNIVERSITAT OF REGENSBURG (DE232 - Regensburg, Kreisfreie Stadt) (Germany), THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD (UKJ14 - Oxfordshire) (Great Britain), CHARITE - UNIVERSITAETSMEDIZIN BERLIN (DE300 - Berlin) (Germany), UNIVERSITY OF LEICESTER (UKF21 - Leicester) (Great Britain), AKADEMISCH ZIEKENHUIS LEIDEN - LEIDEN UNIVERSITAIR MEDISCH CENTRUM (NL331 - Agglomeratie Leiden en Bollenstreek) (Netherlands), GSF - FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH (DE21 - Oberbayern) (Germany), EESTI BIOCENTRE - ESTONIAN BIOCENTRE (EE008 - Lõuna-Eesti) (Estonia), THE UNIVERSITY OF EDINBURGH (UKM25 - Edinburgh, City of) (Great Britain), MAGYAR TUDOMANYOS AKADEMIA (HU333 - Csongrad) (Hungary), MEDICAL RESEARCH COUNCIL (UKI11 - Inner London - West) (Great Britain), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR101 - Paris) (France), UNIVERSITE DE GENEVE (CH012 - Valais) (Switzerland), UNIVERSITY OF SURREY (UKJ23 - Surrey) (Great Britain), AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (CZ010 - Hlavni mesto Praha) (Czech Republic), ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM (NL335 - Groot-Rijnmond) (Netherlands), UNIVERSITAET BASEL (CH056 - Graubünden) (Switzerland), INSTITUTE OF INTERNAL MEDICINE-SIBERIAN BRANCH OF RUSSIA ACADEMY OF MEDICAL SCIENCES (NoRegion - NoRegion) (Russia), LUX BIOTECHNOLOGY LTD (UKM25 - Edinburgh, City of) (Great Britain), GABRIELE HOENIG (DE276 - Augsburg, Landkreis) (Germany), NEWBEHAVIOR AG (CH04 - Zürich) (Switzerland), PERSONAL HEALTH INSTITUTE INTERNATIONAL VOF (NL326 - Groot-Amsterdam) (Netherlands), SOWOON TECHNOLOGIES SARL (CH022 - Freiburg) (Switzerland), BUEHLMANN LABORATORIES AG (CH056 - Graubünden) (Switzerland), QUEEN MARY AND WESTFIELD COLLEGE, UNIVERSITY OF LONDON (UKI11 - Inner London - West) (Great Britain)

The circadian clock is a basic biological process that enables organisms to anticipate daily environmental changes by adjusting behaviour, physiology and gene regulation. It impacts health and quality of life in regulating sleep and well-being, in the consequences of shift-work, in medical diagnosis/therapy, and in age-related changes. A critical feature of the clock is its synchronisation to the external day (entrainment). Entrainment is the key to understanding the circadian clock and its control mechanisms. In EUCLOCK, highly competitive European researchers join forces to investigate the circadian clock under entrainment using the most advanced methods of functional genomics and phenomics comparing powerful genetic model organisms (humans, mice, flies, and yeast). Its four major innovations will shape the future of circadian research: 1) To compare genomic and phenomic aspects of the clock, SOPs will be developed for the first time that mimic aspects of the natural day (dawn/dusk, day-lengths, etc). 2) Protocols, devices and algorithms will be developed, enabling for the first time large-scale, non-invasive research on human entrainment in the field.3) Developing the first animal models for shift-work, making animals 'work' and feed out of phase with their natural rhythms.The ensuing "dys-entrainment" will be investigated at all levels, aiming to provide the insights needed to treat the symptoms and consequences of human shift-work.4) Building on genome sequences, new genetic components and interactions will be identified that control the circadian clock and its entrainment. For the first time the experimental advantages of yeast will be extensively used. The tractability of yeast permits integration and reconstruction of elements and interactions gleaned from other systems. Together, these approaches allow systems biology research on circadian timing to be performed and integrated at the level of the genome, the proteome, and the metabolome.

PERSONS (29/29)

RELATED NAVIGATION AREA(S) (1/1)