ENDOTRACK - Tracking the Endocytic Routes of Growth Factor Receptor Complexes and their Modulatory Role on Signalling (FP6-LIFESCIHEALTH) (2006-02-01 - 2010-01-31) (»add to infobox)

Marino ZERIAL, Danny HUYLEBROECK, Carl-Henrik HELDIN, Christoph NIEHRS, Marta MIACZYNSKA, Jean-Paul VINCENT, Michael BRAND, John HEATH, Jim SMITH, Carol MURPHY, Pierre COLAS

MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV (DE212 - München, Kreisfreie Stadt) (Germany), VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW (BE234 - Arr. Gent) (Belgium), LUDWIG INSTITUTE FOR CANCER RESEARCH UPPSALA BRANCH (SE021 - Uppsala län) (Sweden), DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG (DE125 - Heidelberg, Stadtkreis) (Germany), INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY (PL127 - Miasto Warszawa) (Poland), MEDICAL RESEARCH COUNCIL (UKI11 - Inner London - West) (Great Britain), TECHNISCHE UNIVERSITAET DRESDEN (DED21 - Dresden, Kreisfreie Stadt) (Germany), THE UNIVERSITY OF BIRMINGHAM (UKG31 - Birmingham) (Great Britain), THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UKH12 - Cambridgeshire CC) (Great Britain), FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (GR43 - Kriti) (Greece), IMAXIO (FR716 - Rhône) (France)

Endocytic trafficking plays a more active role in the regulation of polypeptide growth factor (GF) signalling than recognized before. Despite great progress in the description of the endocytic routes and their molecular regulation, we are far from a complete understanding of the endocytic trafficking of GF receptor (GFR) complexes and to which extent their signalling activity requires and is modulated by these routes. The EndoTrack project aims at filling this gap by gaining basic knowledge of the relationship between the endocytic transport and signalling activity of GFRs. EndoTrack combines leading European interdisciplinary research teams to pursue the following aims: 1. To define the trafficking routes of various GFR complexes in cultured cells with an unprecedented degree of precision, combining high-throughput microscopy, electrochemiluminescence technology and automated image analysis. 2. To define the molecular machinery responsible for this transport, using proteomics and functional genomics approaches, and generate proof of concept that trafficking contributes to GF signalling activity in cultured cells. 3. To integrate the information from cultured cells with in vivo studies on animal model systems, in particular Drosophila, zebrafish, Xenopus and mouse. 4. To test the relevance of the modulation of endocytic trafficking on signal transduction in disease model systems. Within 4 years, the use of knockdown approaches, reporter cell lines and animals, combined with target validation proprietary technology from the biotech SMEs, will provide a new generation of assays to measure GFR trafficking and signalling. These assays will lead to novel key regulatory components, and therefore a new generation of diagnostic markers and potential targets for modulation of GF signalling and for the treatment of human diseases. EndoTrack's translational research will thus strengthen the innovation potential of European biotech and pharmaceutical industry.

PERSONS (11/11)

RELATED NAVIGATION AREA(S) (1/1)