BIOXHIT - Biocrystallography (X) on a Highly Integrated Technology Platform for European Structural Genomics (FP6-LIFESCIHEALTH) (»add to infobox)

Victor LAMZIN, Sean MCSWEENEY, Colin NAVE, Clemens SCHULZE-BRIESE, Gerard BRICOGNE, Anastassis PERRAKIS, Kristina DJINOVIC CARUGO, Keith Sanderson WILSON, Uwe MUELLER, Christian CAMBILLAU, George SHELDRICK, Andrew THOMPSON, Cristina CASCHETTO, Marjolein THUNNISSEN, Sine LARSEN, Elizabeth DUKE, Joan BORDAS, Edgar WECKERT, Martin RADITSCH

EUROPAISCHES LABORATORIUM FUER MOLEKULARBIOLOGIE - EMBL (DE125 - Heidelberg, Stadtkreis) (Germany), INSTALLATION EUROPEENNE DE RAYONNEMENT SYNCHROTRON (FR714 - Isère) (France), COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS (UK523 - Oxfordshire) (Great Britain), PAUL SCHERRER INSTITUT (CH053 - Appenzell Ausserrhoden) (Switzerland), GLOBAL PHASING LIMITED (UKH12 - Cambridgeshire CC) (Great Britain), HET NEDERLANDS KANKER INSTITUUT / ANTONI VAN LEEUWENHOEK HOSPITAL (NL326 - Groot-Amsterdam) (Netherlands), SINCROTRONE TRIESTE SCPA (ITD43 - Gorizia) (Italy), UNIVERSITY OF YORK (UKE21 - York) (Great Britain), FREIE UNIVERSITAET BERLIN (DE300 - Berlin) (Germany), UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II (FR824 - Bouches-du-Rhône) (France), GEORG-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENTLICHEN RECHTS (DE915 - Göttingen) (Germany), SOCIETE CIVILE SYNCHROTRON SOLEIL (FR104 - Essonne) (France), IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (ITC45 - Milano) (Italy), LUNDS UNIVERSITET (SE044 - Skåne län) (Sweden), KOBENHAVNS UNIVERSITET (DK001 - København og Frederiksberg kommuner) (Denmark), DIAMOND LIGHT SOURCE LIMITED (UK523 - Oxfordshire) (Great Britain), CONSORCI LABORATORI DE LLUM DE SINCROTRO (ES511 - Barcelona) (Spain), STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY (DE600 - Hamburg) (Germany), EMBL ENTERPRISE MANAGEMENT TECHNOLOGY TRANSFER GMBH (DE125 - Heidelberg, Stadtkreis) (Germany)

The ability of post-genomic research in biology and medicine to deliver substantial improvements in human health depends critically on the rate of progress towards the understanding of complex biological processes at the molecular level, which in turn depends on our capability of rapidly determining the 3D structures of all molecules involved in atomic detail. The BIOXHIT project will develop, assemble and provide an integrated platform for high-throughput structure determination using X-ray crystallography with synchrotron radiation, which will boost such capabilities throughout Europe. X-ray crystallography is the natural choice by virtue of its accuracy, speed, and potential for further speed gains, while synchrotron radiation is indispensable because of its intensity and tuneability. BIOXHIT will coordinate scientists at all European synchrotrons and leading software developers in both academic and industrial groups in a timely and unprecedented joint effort, under an efficient management structure. It will achieve increasing levels of automation and will implement "smart" data collection protocols capable of delivering expert-quality results to non-expert users. Strong emphasis will be placed on integrating the work of hitherto separate teams by early planning for standardisation and transferability, thus maximising cost-effectiveness and fostering a culture of Europe-wide concertation and exchange. A proactive training effort will first take place at synchrotron facilities, then spread to satellite centres for further dissemination. The Project will culminate with the provision of remote access to the BIOXHIT high-throughput facilities from the users' own laboratories or companies. These capabilities will be of lasting benefit to European research, underpinning all future European efforts in Structural and Functional Genomics, and thus helping Europe to occupy a leading position in this field against intense competition from US and Japan.

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