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HCV INHIBITORS - Design of novel inhibitors of hcv rna helicase - potential antivirals for treatment and protection against hepatitis c virus-induced diseases (HCV INHIBITORS) (LIFE QUALITY) (2002-09-01 - 2005-12-31)
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N. N. INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES,
N. N. BERNHARD-NOCHT-INSTITUTE FOR TROPICAL MEDICINE,
N. N. FREIE UNIVERSITAET BERLIN,
N. N. INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,
N. N. INSTITUTE OF ORGANIC INDUSTRY,
N. N. INSTYTUT MEDYCYNY DOSWIADCZALNEJ I KLINICZNEJ POLSKIEJ AKADEMII NAUK
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INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES (PL075 - Mazowieckie Miasto na Prawach Powiatu) (Poland),
BERNHARD-NOCHT-INSTITUT FUR TROPENMEDIZIN (DE600 - Hamburg) (Germany),
FREIE UNIVERSITAET BERLIN (DE300 - Berlin) (Germany),
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR716 - Rhône) (France),
INSTITUTE OF ORGANIC INDUSTRY (PL0C2 - Slaskie Poludniowoslaski) (Poland),
INSTYTUT MEDYCYNY DOSWIADCZALNEJ I KLINICZNEJ POLSKIEJ AKADEMII NAUK (PL075 - Mazowieckie Miasto na Prawach Powiatu) (Poland) |
| BUDGET: | 1.195.224 € |
| FUNDING: | 986.997 € |
| INSTRUMENT: | Cost Sharing Contracts |
| PROGRAMME: | LIFE QUALITY |
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Hepatitis C virus (HCV) infections lead to liver cirrhosis and hepatocellular carcinoma. Currently no efficient drug or vaccine is available. A team of 6 European laboratories from D, F, PL will synthesise and investigate the psycho-chemical and biological properties of a broad range of new modified nucleoside derivatives, guanine, trampoline and anthracycline analogy and their prod rugs, potential inhibitors of HCV RNA helices, a novel and promising target for anti- HCV therapy. The interactions of analogy with HCV helices will be investigated with the use of kinetic methods, crystallography, and multidimensional NMR and CD spectroscopy. Inhibitory activity against HCV helices will be verified in vitro in HCV-infected human macrophages, in human hepatocytes and in yeast cell system. This research should deliver new anti-HCV drugs and may improve the quality of life of millions of HCV-infected patients.
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| PERSONS (6/6) |
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N. N. INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES (Contact / INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES (PL075 - Mazowieckie Miasto na Prawach Powiatu) (Poland))
N. N. BERNHARD-NOCHT-INSTITUTE FOR TROPICAL MEDICINE (Contact / BERNHARD-NOCHT-INSTITUT FUR TROPENMEDIZIN (DE600 - Hamburg) (Germany))
N. N. FREIE UNIVERSITAET BERLIN (Contact / FREIE UNIVERSITAET BERLIN (DE300 - Berlin) (Germany))
N. N. INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (Contact / INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR716 - Rhône) (France))
N. N. INSTITUTE OF ORGANIC INDUSTRY (Contact / INSTITUTE OF ORGANIC INDUSTRY (PL0C2 - Slaskie Poludniowoslaski) (Poland))
N. N. INSTYTUT MEDYCYNY DOSWIADCZALNEJ I KLINICZNEJ POLSKIEJ AKADEMII NAUK (Contact / INSTYTUT MEDYCYNY DOSWIADCZALNEJ I KLINICZNEJ POLSKIEJ AKADEMII NAUK (PL075 - Mazowieckie Miasto na Prawach Powiatu) (Poland))
| RELATED NAVIGATION AREA(S) (4/4) |
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Cancerology
FP5 Life Quality
IFR 62
Infectiology
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