OLDCLOCK - Ageing and the biological clock in the brain (OLDCLOCK) (LIFE QUALITY) (2003-01-01 - 2005-12-31) (»add to infobox)

Heather MARSHALL-HEYMAN, Annie LECHEVALLIER, Christian BRECHOT, Elio MOSELE

KAROLINSKA INSTITUTET (SE010 - Stockholms län) (Sweden), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR104 - Essonne) (France), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR716 - Rhône) (France), UNIVERSITA DEGLI STUDI DI VERONA (ITD31 - Verona) (Italy)

The objective of the present project is to decipher basic cellular and molecular processes that underlie disturbances in the control of biological rhythms withageing. The suprachiasmatic nucleus (SCN) plays a role of biological clock and is unique for studies of ageing phenomena at the cellular and molecular level that can be correlated to a distinct function, the regulation of biological rhythms, which undergoes major changes with ageing to deteriorate the quality of life. Despite the clinical evidence that biological rhythms are disrupted in elderly people, little is known about the molecular, cellular and functional changes occurring in the SCN with ageing. In the proposed project we will study changes of factors intrinsic to the neurons in the SCN as well as extrinsic factors in humans and experimental systems. The latter includes effects on the SCN by cytokines that increase in the blood and the brain in awed individuals.

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