IMMUNOTSE - Passage from intestine to brain: assessing the role of dendritic cells in capturing, expanding and disseminating prions (LIFE QUALITY) (2002-11-01 - 2006-04-30) (»add to infobox)

Claudine CHEMLA, Christian BRECHOT, Andrew S. GRICE, Anne-Marie CORIAT, Anton BERNS, Willy LEGROS, Gilbert BEREZIAT, Pierre ESPINASSE

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR101 - Paris) (France), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR714 - Isère) (France), INSTITUTE FOR ANIMAL HEALTH (UK521 - Berkshire) (Great Britain), MEDICAL RESEARCH COUNCIL (UK550 - Greater London) (Great Britain), NETHERLANDS CANCER INSTITUTE/ANTONI VAN LEEUWENHOEK HOSPITAL (NL326 - Groot-Amsterdam) (Netherlands), UNIVERSITE DE LIEGE (BE332 - Arr. Liège) (Belgium), UNIVERSITE PIERRE ET MARIE CURIE (FR101 - Paris) (France), UNIVERSITY OF OXFORD (UK523 - Oxfordshire) (Great Britain)

The aim of the proposal is to identify potential therapeutic targets at the pre-clinical stages of transmissible spongiform encephalopathies (TSE). Studies will demonstrate and characterize the roles of dendrite cells (Daces) in the propagation at TSE agents (prisons) to the nervous system. Daces are involved at multiple levels of the infectious process, and their properties and functions might be manipulated. The following steps will be analysed: Penetration through the gut epithelium Accumulation in the associated-associated lymphoid tissue Spreading to other lymphoid organs Factors of prison propagation (complement, receptors and receptors) Spreading from lymphoid structures to the nervous system The in vivo research may not be performed on naturally infected subjects, and must use a relevant experimental model, i.e. a standard oral inoculation protocol with well-defined mouse experimental scrape strains. Finally, certain studies will require in vitro analyses, especially those aimed at identifying molecular interactions.

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