MYORES - Multi-Organismic Approach to Study Normal and Aberrant Muscle Development, Function and Repair (FP6-LIFESCIHEALTH) (2005-01-01 - 2009-12-31) (»add to infobox)

Krzysztof JAGLA, Christophe MARCELLE, Anne-Gaelle BORICKY, Beate BRAND-SABERI, Baljinder MANKOO, Andrea MÜNSTERBERG, Michael Victor TAYLOR, Margaret E. BUCKINGHAM, Eileen FURLONG, Bernard THISSE, Hans-Henning ARNOLD, Stefano SCHIAFFINO, Tomas SOUKUP, Renate RENKAWITZ-POHL, Carmen BIRCHMEIER, Alberto FERRUS, Chaya KALCHEIM, John Michael SQUIRE, John SPARROW, Vincent MOULY, Thomas BRAUN, Peter RIGBY, Jonathan DANDO, Laurent SEGALAT

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR101 - Paris) (France), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR101 - Paris) (France), THE UNIVERSITY OF SHEFFIELD (UKE32 - Sheffield) (Great Britain), UNIVERSITAETSKLINIKUM FREIBURG (DE131 - Freiburg im Breisgau, Stadtkreis) (Germany), KING'S COLLEGE LONDON (UKI11 - Inner London - West) (Great Britain), UNIVERSITY OF EAST ANGLIA (UKH13 - Norfolk) (Great Britain), CARDIFF UNIVERSITY (UKL22 - Cardiff and Vale of Glamorgan) (Great Britain), INSTITUT PASTEUR (FR101 - Paris) (France), EUROPAISCHES LABORATORIUM FUER MOLEKULARBIOLOGIE - EMBL (DE125 - Heidelberg, Stadtkreis) (Germany), CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE (FR421 - Bas-Rhin) (France), TECHNISCHE UNIVERSITAET CAROLO-WILHELMINA ZU BRAUNSCHWEIG (DE911 - Braunschweig, Kreisfreie Stadt) (Germany), UNIVERSITA DEGLI STUDI DI PADOVA (ITD36 - Padova) (Italy), AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (CZ010 - Hlavni mesto Praha) (Czech Republic), PHILIPPS UNIVERSITAET MARBURG (DE724 - Marburg-Biedenkopf) (Germany), MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN (DE300 - Berlin) (Germany), CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES300 - Madrid) (Spain), THE HEBREW UNIVERSITY OF JERUSALEM (ME04 - Israel) (Israel), IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (UKI11 - Inner London - West) (Great Britain), UNIVERSITY OF YORK (UKE21 - York) (Great Britain), UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI (FR101 - Paris) (France), MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV (DE212 - München, Kreisfreie Stadt) (Germany), INSTITUTE OF CANCER RESEARCH - ROYAL CANCER HOSPITAL (UKI11 - Inner London - West) (Great Britain), INSERM - TRANSFERT SA (FR101 - Paris) (France), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR716 - Rhône) (France)

In Europe over 300.000 people are affected by muscular dystrophies whilst the majority of the aged population are affected by muscle degeneration leading to decreased mobility and loss of independence. This has severe consequences at both a personal and economic level. The aim of this proposal is to understand how these muscular defects can be repaired. Thus, the proposed project will restructure European research and will: i) integrate internationally recognised European specialists working on various aspects of muscle biology and pathology in a number of model organisms; ii) federate their research on well defined aims and obtain a critical mass of researchers who will be able to make significant scientific advancements; iii) create state-of-the-art technical platforms and resources which will serve the network's scientific aims; iv) organize the rapid transfer and application of knowledge acquired in genetically amenable organisms into specific applications for human muscle diseases; v) broadly publicize our scientific action and, through education, attract younger generation of scientists into this essential field of research. All aspects of muscle differentiation are to be investigated and this will be translated into the mechanisms of repair in the adult. Fundamental to the advancement of our knowledge is the recent demonstration that, throughout evolution, many of the molecular mechanisms regulating muscle differentiation have been highly conserved. As molecular pathways can be easily assessed in invertebrates, we will exploit this advantage and rapidly extend the knowledge gained in these systems to determine gene function in higher vertebrates. This is a unique aspect of the proposal and places the consortium at the international forefront of understanding of gene function during normal muscle development and disease.'

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