CHRONIC RAD EPID - QUANTIFICATION OF CANCER AND NON-CANCER RISKS ASSOCIATED WITH MULTIPLE CHRONIC RADIATION EXPOSURES: EPIDEMIOLOGICAL STUDIES, ORGAN DOSE CALCULATION AND RISK ASSESSMENT (FRAMEWORK 6C) (2005-07-01 - 2008-06-30) (»add to infobox)

Margot TIRMARCHE, George SALLIT, Bernd GROSCHE, Matthias MOEHNER, Carlo MACCIA, Sarah Caroline DARBY, Irene BRÜSKE-HOHLFELD, Colin MUIRHEAD, Elisabeth CARDIS, Francesco BOCHICCHIO, Harmen BIJWAARD, William David ATKINSON, Ladislav TOMASEK, Lucas HOLMSTOCK, Adrian P. FOSTER, Werner HOFMANN, Daniel KREWSKI, Keith BINKS

INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE (FR105 - Hauts-de-Seine) (France), AWE PLC (UK521 - Berkshire) (Great Britain), BUNDESAMT FUER STRAHLENSCHUTZ (DE912 - Salzgitter, Kreisfreie Stadt) (Germany), BUNDESANSTALT FUER ARBEITSSCHUTZ UND ARBEITSMEDIZIN (DE300 - Berlin) (Germany), CAATS SARL (FR105 - Hauts-de-Seine) (France), CANCER RESEARCH UK (UK550 - Greater London) (Great Britain), GSF - FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH (DE21H - München, Landkreis) (Germany), HEALTH PROTECTION AGENCY (UK550 - Greater London) (Great Britain), INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (FR716 - Rhône) (France), ISTITUTO SUPERIORE DI SANITA (ITE43 - Roma) (Italy), RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (NL310 - Utrecht) (Netherlands), RWE NUKEM LIMITED (UK810 - Cheshire) (Great Britain), STATNI USTAV RADIACNI OCHRANY (CZ010 - Hlavni mesto Praha) (Czech Republic), STUDIECENTRUM VOOR KERNENERGIE - CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE (BE100 - Arr. de Bruxelles-Capitale) (Belgium), UNITED KINGDOM ATOMIC ENERGY AUTHORITY (UK523 - Oxfordshire) (Great Britain), UNIVERSITAET SALZBURG (AT323 - Salzburg und Umgebung) (Austria), UNIVERSITY OF OTTAWA (CA07 - Ontario) (Canada), WESTLAKES SCIENTIFIC CONSULTING LIMITED (UK12 - Cumbria) (Great Britain)

Radiation protection guidelines are mainly based on studies of populations exposed to external radiation. This project regroups major European studies able to evaluate long term health effects after internal exposure to radionuclides (radon, uranium, plutonium). Large cohort and case-control studies aim to quantify the effect of multiple exposures, taking into account specific organ dose calculation, the contribution of each radionuclides and external exposure. All selected studies are characterized by precise registration of individual annual exposure:-German, French and Czech Uranium miner cohorts, implemented during a FP5 project will inform on quantification of risk for various cancers (lung, kidney, leukaemia) and non-cancer in relation to calculated organ dose by producing recent data, but also including dust and gamma exposure. -European case-control studies on lung cancer and domestic radon gives the opportunity to compare these risk estimates with those from worker studies and to calculate attributable risk for low protracted exposures to alpha particles and interactions with tobacco. -Specific studies of nuclear workers in which doses due to internal contaminations will be reconstructed individually, especially in the UK, France and Belgium. The main interest will be on lung cancer and leukaemia risk, through nested case-control studies. Implementation of a joint French-English cohort will provide the bases for studies of long term health effects of internal and external exposures. Uncertainties linked to exposure estimates will be introduced into dose-risk models. Researchers in epidemiology, statistics, modelling and dosimetry will constitute a European panel supporting the data analysis and the interpretation of results. This project will provide integrated results regarding effects of chronic internal radiation exposures, complementarily to other ongoing work, mainly on Mayak.

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