CASCADE - Chemicals as contaminants in the food chain: an NOE for research, risk assessment and education (FP6-FOOD) (2004-02-01 - 2009-01-31) (»add to infobox)

Jan-Åke GUSTAFSSON, Barbara DEMENEIX, Guenter GAUGLITZ, Vincent LAUDET, Wolfgang WUTTKE, Martin GOTTLICHER, Olli JÄNNE, Jean-Pierre CRAVEDI, Francesco BRANCA, Christian BEHL, Konrad KOEHLER, Emilio BENFENATI, Juan MORALES SANCHEZ, Wout SLOB, Nicolas OLEA SERRANO, Adriana MAGGI, Janos GARAI, Sari Iiona MÄKELÄ

KAROLINSKA INSTITUTET (SE010 - Stockholms län) (Sweden), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR101 - Paris) (France), EBERHARD-KARLS UNIVERSITAET TUEBINGEN (DE142 - Tübingen, Landkreis) (Germany), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR716 - Rhône) (France), GEORG-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENTLICHEN RECHTS (DE915 - Göttingen) (Germany), GSF - FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH (DE21H - München, Landkreis) (Germany), HELSINGIN YLIOPISTO (FI181 - Uusimaa) (Finland), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (FR101 - Paris) (France), ISTITUTO NAZIONALE DI RICERCA PER GLI ALIMENTI E LA NUTRIZIONE (ITE43 - Roma) (Italy), JOHANNES GUTENBERG UNIVERSITAET MAINZ (DEB35 - Mainz, Kreisfreie Stadt) (Germany), KARO BIO AB (SE010 - Stockholms län) (Sweden), MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH (IT205 - Milano) (Italy), PULEVA BIOTECH S.A. (ES614 - Granada) (Spain), RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (NL310 - Utrecht) (Netherlands), UNIVERSIDAD DE GRANADA (ES614 - Granada) (Spain), UNIVERSITY OF MILANO (IT205 - Milano) (Italy), UNIVERSITY OF PÉCS (HU041 - Del-Dunantul Baranya) (Hungary), UNIVERSITY OF TURKU (FI121 - Varsinais-Suomi) (Finland)

The harmful effects of dietary chemical contaminants represent a major health problem in every society. However since there is insufficient information it has proved difficult to assess the health risks they constitute for humans, especially women, newborn children, and other susceptible populations. Nuclear receptors regulate critical cellular processes such as cell growth and differentiation, metabolic processes and other. Endocrine disrupting agents, acting through nuclear receptors, are thus involved in many different pathological situations such as tumour development, metabolic disease and obesity, coronary heart problems etc. Europe has recognized this threat and extensive research efforts have been undertaken to identify the problems caused by food borne contaminants. However, the full European potential in this area of research has not been utilised because European research is fragmented. There is little coordination of the European research and this lack of integration results in a sub optimal European research atmosphere. To address this issue 18 Universities and Sees have decided to form a European wide Network of Excellence (Noël) under the leadership of the Karolin?s Institutet.We will harmonize the whole chain of events from sampling procedures, to risk assessment and legislative measures. The participation of multiple research areas will facilitate greater efficiency of data production, information flow and communication of knowledge in key areas such as sampling methods, identification and analysis of chemical residues and identification of relevant marker proteins. End results will include training programmes and provision of rationalised information for assessing the risk that these compounds pose to human health. Channelling information to the general public will be emphasised so that the scientific information will be used by consumers and for implementation of legislative measures.

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