|
CANCERRISKBIOMARKERS - Cytogenetic biomarkers and human cancer risk (LIFE QUALITY) (2001-01-01 - 2004-12-01)
(»add to infobox)
 
|
Jorma RANTANEN,
Eva SYKOVA,
Giorgio DELLACASA,
Paul KLEIHUES,
Marek ZEMBALA,
Peter NILSSON-EHLE,
Miklos KASLER,
Jaroslav KRIZ,
Sisko SALOMAA,
N. N. FABIANOVA,
Stein Inge FANDREM,
Els WITTE,
Benediktas JUODKA
|
|
FINNISH INSTITUTE OF OCCUPATIONAL HEALTH (FI110 - Uusimaa) (Finland),
INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ010 - Hlavni mesto Praha) (Czech Republic),
INSTITUTO NAZIONALE PER LA RICERCA SUL CANCRO (IT133 - Genova) (Italy),
INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (FR716 - Rhône) (France),
JAGIELLONIAN UNIVERSITY (PL211 - Krakowsko-tarnowski) (Poland),
LUNDS UNIVERSITET (SE043 - Malmoehus Laen) (Sweden),
NATIONAL INSTITUTE OF ONCOLOGY (HU101 - Budapest) (Hungary),
NATIONAL INSTITUTE OF PUBLIC HEALTH (CZ) (CZ010 - Hlavni mesto Praha) (Czech Republic),
RADIATION AND NUCLEAR SAFETY AUTHORITY (FI110 - Uusimaa) (Finland),
STATE HEALTH INSTITUTE (SK032 - Banskobystricky kraj) (Slovakia),
TELEMARK CENTRAL HOSPITAL (NO034 - Telemark) (Norway),
UNIVERSITE LIBRE DE BRUXELLES (BE100 - Arr. de Bruxelles-Capitale) (Belgium),
VILNIUS UNIVERSITY (LT00A - Vilniaus apskritis) (Lithuania) |
| BUDGET: | 1.828.058 € |
| FUNDING: | 1.300.000 € |
| INSTRUMENT: | Cost Sharing Contracts |
| PROGRAMME: | LIFE QUALITY |
|
|
|
The partners have previously shown that a high frequency of chromosomal aberrations (CAs) in peripheral lymphocytes is predictive of increased cancer risk, regardless of smoking or occupational carcinogen exposure. The present multidisciplinary project aims at clarifying the reasons for these findings. Archived cell specimens of subjects earlier examined for cytogenesis biomarkers will be analysed for major genetic polymorphisms suspected to affect chromosome damage. These data will be used to reveal those Polymorphisms that modify the frequency of CAs and of sister chromatic exchanges (SCEs) and the cancer association of CAs. The existing cohorts will be re-examined to identify the types of CAs indicative of cancer risk and to re-evaluate if SCEs predict cancer. Two new European cohorts will be assembled, one to confirm the findings on CAs and SCEs and to study association with major cancer types, and another to see if cancer risk is predicted by lymphocyte micronucleus frequency.
|
| PERSONS (13/13) |
|
Jorma RANTANEN (Contact / FINNISH INSTITUTE OF OCCUPATIONAL HEALTH (FI110 - Uusimaa) (Finland))
Eva SYKOVA (Contact / INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ010 - Hlavni mesto Praha) (Czech Republic))
Giorgio DELLACASA (Contact / INSTITUTO NAZIONALE PER LA RICERCA SUL CANCRO (IT133 - Genova) (Italy))
Paul KLEIHUES (Contact / INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (FR716 - Rhône) (France))
Marek ZEMBALA (Contact / JAGIELLONIAN UNIVERSITY (PL211 - Krakowsko-tarnowski) (Poland))
Peter NILSSON-EHLE (Contact / LUNDS UNIVERSITET (SE043 - Malmoehus Laen) (Sweden))
Miklos KASLER (Contact / NATIONAL INSTITUTE OF ONCOLOGY (HU101 - Budapest) (Hungary))
Jaroslav KRIZ (Contact / NATIONAL INSTITUTE OF PUBLIC HEALTH (CZ) (CZ010 - Hlavni mesto Praha) (Czech Republic))
Sisko SALOMAA (Contact / RADIATION AND NUCLEAR SAFETY AUTHORITY (FI110 - Uusimaa) (Finland))
N. N. FABIANOVA (Contact / STATE HEALTH INSTITUTE (SK032 - Banskobystricky kraj) (Slovakia))
Stein Inge FANDREM (Contact / TELEMARK CENTRAL HOSPITAL (NO034 - Telemark) (Norway))
Els WITTE (Contact / UNIVERSITE LIBRE DE BRUXELLES (BE100 - Arr. de Bruxelles-Capitale) (Belgium))
Benediktas JUODKA (Contact / VILNIUS UNIVERSITY (LT00A - Vilniaus apskritis) (Lithuania))
| RELATED NAVIGATION AREA(S) (2/2) |
|
Cancerology
FP5 Life Quality
|
|
|
|
