VIZIER - Comparative Structural Genomics of Viral Enzymes Involved in Replication (FP6-LIFESCIHEALTH) (2004-11-01 - 2008-10-31) (»add to infobox)

Christian CAMBILLAU, Alexander GORBALENYA, Ernest GOULD, Helene NORDER, Milan LABUDA, Hervé BOURHY, Jacques ROHAYEM, Kenneth LUNDSTRÖM, David Ian STUART, Paul TUCKER, Martino BOLOGNESI, Andrea MATTEVI, Miquel COLL, Gerard BRICOGNE, T. Alwyn JONES, Rolf HILGENFELD, Johan NEYTS, Paolo LA COLLA, Heinz FELDMANN, Stuart NICHOL, Andrey M. LEONTOVICH, Pär NORDLUND, Tania LANGON

BILKENT UNIVERSITESI (TR51 - Ankara) (Turkey), CENTRAL LABORATORY OF OPTICAL STORAGE AND PROCESSING OF INFORMATION (BG211 - Sofia (stolitsa)) (Bulgaria), DE MONTFORT UNIVERSITY (UKF21 - Leicester) (Great Britain), FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG EV (DE212 - München, Kreisfreie Stadt) (Germany), FOGSCREEN OY (FI194 - Etelä-Pohjanmaa) (Finland), TECHNISCHE UNIVERSITAET ILMENAU (DEG0F - Ilm-Kreis) (Germany), TAMPEREEN TEKNILLINEN YLIOPISTO (FI192 - Pirkanmaa) (Finland), CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS (GR122 - Thessaloniki) (Greece), KOC UNIVERSITY (TR1 - Istanbul) (Turkey), ORTA DOGU TEKNIK UNIVERSITESI (TR51 - Ankara) (Turkey), MOMENTUM BILGISAYAR YAZILIM DANISMANLIK TICARET ANONIM SIRKETI (TR421 - Kocaeli) (Turkey), MAX-PLANCK-INSTITUT FUER INFORMATIK (DEC01 - Stadtverband Saarbrücken) (Germany), ZAPADOCESKA UNIVERZITA V PLZNI (UNIVERSITY OF WEST BOHEMIA) (CZ032 - Plzensky kraj) (Czech Republic), GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER (DE929 - Region Hannover) (Germany), TECHNISCHE UNIVERSITAET BERLIN (DE300 - Berlin) (Germany), EBERHARD-KARLS UNIVERSITAET TUEBINGEN (DE142 - Tübingen, Landkreis) (Germany), UNIVERSITY OF ABERDEEN (UKM10 - Aberdeen City, Aberdeenshire and North East Moray) (Great Britain), YOGURT BILGISAYAR TEKNOLOJILERI TICARET LIMITED SIRKETI (TR1 - Istanbul) (Turkey), UNIVERSITY OF MANITOBA (NoRegion - NoRegion) (Canada), CENTERS FOR DISEASE CONTROL AND PREVENTION (NoRegion - NoRegion) (Usa), GENEBEE GROUP (NoRegion - NoRegion) (Russia), STOCKHOLMS UNIVERSITET (SE010 - Stockholms län) (Sweden), ALMA CONSULTING GROUP SAS (FR716 - Rhône) (France)

This project aims to perform a ground-breaking impact on the identification of potential new drug targets against RNA viruses through comprehensive structural characterisation of the replicative machinery of -300 RNA viruses. RNA viruses are major human pathogens (>350 identified) causing millions of deaths annually. The VIZIER team brings together the leading authorities on RNA viruses available in EU & more, with P4 facilities, as well as leaders in the field of structural genomics, with an adapted Management & Training structure. VIZIER aims to characterise RNA viruses (no DNA stage in their repl. cycle) of 3 genetically different classes: double-stranded and single stranded RNA viruses with positive & negative polarity. Their replicative machineries are the most conserved and essential viral components, thus are attractive targets for antivirus therapy. The core enzymes/proteins of the replication machinery (polymerases, helicases, capping enzymes, NTPases, proteases, ancillary replicative proteins) will be characterised and compared. One unique feature of VIZIER is the integration of major structural effort within a broad multidisciplinary study, having virology upstream and target validation (lead design) downstream. As a result, the implementation plan of the VIZIER project is structured into 5 interacting scientific sections: (i) bioinformatics, for genome annotation, target selection and data integration; (ii) virus production and genome sequencing; (iii) HTP protein production (2000-3000 targets); (iv) HTP crystallization and structural determination and (v) target validation, to assess the function of enzymes and design strategies for virus inhibition. New tools for protein production and distributed X-ray crystallography will be developed and validated. This latter aspect will provide a new mechanism for the fast dissemination of the gained knowledge and expertise within the European Union, inside and outside the #

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