DIOGENES - Diet, Obesity and Genes (FP6-FOOD) (2005-01-01 - 2009-12-31) (»add to infobox)

Wim SARIS, Petra BUDDE, Thorkild SOERENSEN, Andras SALGO, Domenico PALLI, Vladimir STICH, Patrick RITZ, Jean-Michel ANTOINE, Andreas F. H. PFEIFFER, Elke ROSCHMANN, Oydis UELAND, Polly PAGE, Svetoslav HANDJIEV, Hilary GREEN, Tony LAM, Alexandra BOELRIJK, Richard Nicholas HILL, Edith FESKENS, James STUBBS, Arne ASTRUP, Rene DE WIJK, Dominique LANGIN, David MELA, J. Alfredo MARTINEZ, Joachim WESTENHOEFER, Anthony KAFATOS, Jaakko KAPRIO, John Edward BLUNDELL, Richard SHEPHERD

UNIVERSITEIT MAASTRICHT (NL423 - Zuid-Limburg) (Netherlands), DIGILAB BIOVISION GMBH (DE929 - Region Hannover) (Germany), BISPEBJERK HOSPITAL (DK001 - København og Frederiksberg kommuner) (Denmark), BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM (HU101 - Budapest) (Hungary), CENTRO PER LO STUDIO E LA PREVENZIONE ONCOLOGICA (ITE14 - Firenze) (Italy), CHARLES UNIVERSITY PRAGUE (CZ010 - Hlavni mesto Praha) (Czech Republic), CORTECNET (FR101 - Paris) (France), DANONE VITAPOLE (FR104 - Essonne) (France), GERMAN INSTITUTE OF HUMAN NUTRITION (DE40E - Potsdam-Mittelmark) (Germany), INTEGRAGEN SA (FR104 - Essonne) (France), MATFORSK - NORWEGIAN FOOD RESEARCH INSTITUTE (NO012 - Akershus) (Norway), MEDICAL RESEARCH COUNCIL (UK550 - Greater London) (Great Britain), NATIONAL MEDICAL TRANSPORT INSTITUTE (BG041 - Yugozapaden Sofia stolitsa) (Bulgaria), NESTEC SA (NoRegion - NoRegion) (Switzerland), NETUNION SARL (CH011 - Vaud) (Switzerland), NIZO FOOD RESEARCH (NL223 - Arnhem/Nijmegen) (Netherlands), RICHARD HILL CONSULTING LTD (UK511 - Bedfordshire) (Great Britain), WAGENINGEN UNIVERSITEIT (NL221 - Veluwe) (Netherlands), ROWETT RESEARCH INSTITUTE (UKA40 - Grampian) (Great Britain), KOBENHAVNS UNIVERSITET (DK001 - København og Frederiksberg kommuner) (Denmark), STICHTING TOPINSTITUUT VOEDSELWETENSCHAPPEN (NL223 - Arnhem/Nijmegen) (Netherlands), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR716 - Rhône) (France), UNILEVER NEDERLAND BV (NL335 - Groot-Rijnmond) (Netherlands), UNIVERSIDAD DE NAVARRA (ES220 - Navarra) (Spain), UNIVERSITY OF APPLIED SCIENCES HAMBURG (DE600 - Hamburg) (Germany), UNIVERSITY OF CRETE (GR43 - Kriti) (Greece), UNIVERSITY OF HELSINKI (FI110 - Uusimaa) (Finland), UNIVERSITY OF LEEDS (UK240 - West Yorkshire) (Great Britain), UNIVERSITY OF SURREY (UK532 - Surrey) (Great Britain)

The rapid growth in the prevalence of obesity and associated co-morbidities, in particular the rise in childhood obesity across Europe are major global health concerns. Susceptibility to obesity is determined largely by genetic factors but the current epidemic is significantly influenced by lifestyle factors. Given our genetic background it is largely infeasible to self-regulate food intake in the current environment. Innovative scientific approaches to the problem are needed. DiOGenes aims to respond by including all disciplines and stakeholders who can contribute to a better understanding of the disease and its alleviation by dietary means. DiOGenes' primary dietary focus is on macronutrients that will facilitate a healthy weight, specifically the role of the carbohydrate Glycemic Index and of a high protein content in enhancing satiety. To examine critically the dietary impact, an 8-country, long-term randomised, parallel dietary intervention study on whole families will take place. To identify gene-nutrient interactions linked with changes in body weight and waist circumference, DiOGenes is uniquely positioned trough access to long-term prospective cohorts across Europe. Large-scale longitudinal analysis of variation in candidate genes, plus approaches such as gene expression in fat tissue and plasma peptidomics, will search for genetic biomarkers, ultimately enabling prediction of individuals' responses to nutrients in terms of weight change, in turn leading to diet-based treatment. The epidemiological and intervention studies will be complemented by innovative analysis of the psychological/behavioural responses of subjects. Food technology studies will seek to develop food combining high consumer liking/preference with enhanced satiety signals to limit intake. Demonstration and dissemination projects will show how these new concepts in individualized weight management based on balanced dietary advice and individual risk.

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