ELISHA - Electronic Immuno-Interfaces and Surface Nanobiotechnology: A Heterodoxical Approach. (FP6-NMP) (2004-01-01 - 2007-06-30) (»add to infobox)

Paul Anthony MILLNER, M Pilar MARCO COLAS, Seamus HIGSON, Benedicte MARTIN, Bertold HOCK, Denise GIBSON, Graham Robert JOHNSON, Serge COSNIER, Cormac HARRINGTON

UNIVERSITY OF LEEDS (UK240 - West Yorkshire) (Great Britain), CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES300 - Madrid) (Spain), CRANFIELD UNIVERSITY (UK511 - Bedfordshire) (Great Britain), ECOLE CENTRALE DE LYON (FR716 - Rhône) (France), TECHNISCHE UNIVERSITAET MUENCHEN (DE212 - München, Kreisfreie Stadt) (Germany), TECHNOLOGY TRANSLATORS LIMITED (UK240 - West Yorkshire) (Great Britain), UNISCAN INSTRUMENTS LTD (UK311 - Derbyshire) (Great Britain), UNIVERSITE JOSEPH FOURIER GRENOBLE 1 (FR714 - Isère) (France), UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (IE025 - South-West (IRL)) (Ireland)

Molecular events occurring at the Nan scale impact on the macroscopic level in many different areas and rules for controlled manufacture at the Nan scale are important to understand. The ELISHA project is designed to improve knowledge in molecular interfaces and enable manufacture of new sensors, by interrogating the formation and signal generation of antibodies and electro conductive surfaces. The project is based on:1) a proven series of experimental observations that antibody loaded electro conductive matrices give concentration dependant responses when interrogated with DC pulsed and AC impedance electronics and 2) the knowledge and belief that the project will bring breakthroughs in Nan scale interfacial electrochemistry, leading to novel generic platforms for electro-interfaced-immunosensors to be produced and commercialised. This is the primary objective of the NMP work programme, "to promote real breakthroughs, based on scientific and technical excellence". The project targets several priority areas in Nan technology, NMP-2002-3.4.1.2.1.'the interface between biological and non-biological entities' and NMP-2002-3.4.4.3 - 'New generations of sensors, actuators and systems for safety and security of people and environment'. Novel materials are expected, NMP-2002- 3.4.2.3.1. And the project is directly in the area of Nan biotechnology, NMP-1.2. The project goes beyond the 'state of the art' in many areas and will give significant strategic impact for the EU, addressing community societal objectives by producing new methods to rapidly detect 1) cancer markers, 2) fluoroquinolines antibiotics and 3) prison type peptides, enabling rapid and point of care detection. The project is structured into 9 work packages including antibody production, sensor fabrication, immobilisation methods, signal generation and electronics production. A prototype instrument is the material deliverable. A world class team of 9 partners has been brought together to make ELISHA a reality.

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