TSE-SOIL-FATE - Biotic and abiotic mechanisms of TSE infectivity retention and dissemination in soil (LIFE QUALITY) (2003-01-01 - 2006-04-30) (»add to infobox)

Daniel BOULET, Martin HIRSCH, Annie LECHEVALLIER, Michel RETOURNA, Veronique DEBISSCHOP, Etienne LANDAIS, Joël MOREAU, John SIME, Andrew S. GRICE, Rudi BALLING, Franco FERRARA, Pietro VIOLANTE, Domitien DEBOUZIE, Jacques BONNAFE, Annie LECHEVALLIER

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (FR813 - Hérault) (France), AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS (FR107 - Val-de-Marne) (France), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR107 - Val-de-Marne) (France), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR101 - Paris) (France), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR716 - Rhône) (France), ECOLE NATIONALE SUPERIEURE AGRONOMIQUE DE MONTPELLIER (FR813 - Hérault) (France), ECOLE NATIONALE SUPÉRIEURE DE CHIMIE DE MONTPELLIER (FR813 - Hérault) (France), IMPERIAL COLLEGE LONDON (UK550 - Greater London) (Great Britain), INSTITUTE FOR ANIMAL HEALTH (UK521 - Berkshire) (Great Britain), NATIONAL CENTRE FOR BIOTECHNOLOGY (DE911 - Braunschweig, Kreisfreie Stadt) (Germany), NATIONAL RESEARCH COUNCIL OF ITALY (IT514 - Firenze) (Italy), UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II (ITF33 - Napoli) (Italy), UNIVERSITE CLAUDE BERNARD LYON 1 (FR716 - Rhône) (France), UNIVERSITE DE MONTPELLIER II (FR813 - Hérault) (France), UNIVERSITE PIERRE ET MARIE CURIE (FR107 - Val-de-Marne) (France)

TSE contamination of soils or water, by infected herds, rotting carcasses or via the storage of rendering waste, is a matter of concern both for sustainability of European breeding activity and human health. The fate of the TSE agent in soils depends on the balance between retention, destruction and dissemination factors, either biotic or abiotic. Physico-chemical mechanisms of prion adsorption to soil mineral colloids or organo-mineral complexes and desorption conditions will be analysed with respect to protein structural entity and modifications of infectivity at both laboratory and field scales. Soil microrganisms presenting TSE infectivity lytic activity, earthworm gut enzymes as well as necrophagous insect larvae will be considered as main biotic agents affecting infectivity, dissemination and persistency. Recommendations will be deduced from scientific results by the end users associated to the consortium.

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