PERILIP - Influence of dietary fatty acids on the pathophysiology of intrauterine foetal growth and neonatal development (LIFE QUALITY) (2002-04-01 - 2005-09-30) (»add to infobox)

William WAKEHAM, John WEBB, Francois GRATEAU, Wolfgang URDL, Dietrich REINHARDT, Paolo MANTEGAZZA

IMPERIAL COLLEGE LONDON (UK550 - Greater London) (Great Britain), COTSWOLD PIG DEVELOPMENT COMPANY (UKF30 - Lincolnshire) (Great Britain), HOSPICES CIVILS DE LYON (FR716 - Rhône) (France), KARL-FRANZENS-UNIVERSITAET GRAZ (AT221 - Graz) (Austria), LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (DE212 - München, Kreisfreie Stadt) (Germany), UNIVERSITY OF MILANO (IT205 - Milano) (Italy)

Prenatal nutrition is known to affect the health and development of the newborn child. A foetus that suffers intra-uterine growth restriction (IUGR) is more likely to suffer from cardiac or diabetic problems in later life, an effect known as "metabolic programming". Particular fatty acids are required for development but the optimum composition of dietary lipids remains controversial. The project will compare normal and IUGR pregnancies in terms of marten, neonatal and placenta fatty acid profiles. Placental transfer of fatty acids in vivo and the functional ability of trophoblasts in vitro will be measured. The effects of dietary fats, on maternal endocrine status, oxidative stress, milk composition, placental function and on the development of IUGR and normal foetuses in uteri (or ex uteri in the case of the preteen infants fed intravenously) will be assessed. Human?s studies will be complemented with appropriate rat and pig animal-models. The results will be used to formulate improved dietary recommendations for mothers throughout pregnancy and lactation.

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