CEGLYC - Combinatorial engineering of glycoside hydrolases from the alpha-amylase superfamily (LIFE QUALITY) (2002-01-01 - 2004-12-31) (»add to infobox)

Louis CASTEX, Povl KROGSGAARD-LARSEN, Veronique DEBISSCHOP, Ejner BECH JENSEN, Domitien DEBOUZIE, Simon K. KUIPERS, Sven FROKJAER

INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE INSAT (FR623 - Haute-Garonne) (France), CARLSBERG A/S (DK001 - København og Frederiksberg kommuner) (Denmark), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR716 - Rhône) (France), NOVOZYMES A/S (DK001 - København og Frederiksberg kommuner) (Denmark), UNIVERSITE CLAUDE BERNARD LYON 1 (FR716 - Rhône) (France), UNIVERSITY MEDICAL CENTER GRONINGEN (NL113 - Overig Groningen) (Netherlands), UNIVERSITY OF PHARMACEUTICAL SCIENCES (DK001 - København og Frederiksberg kommuner) (Denmark)

The aim of the CEGLYC project is to apply combinatorial engineering approaches to obtain improved enzymes with high catalytic efficiency and better specificity and stability. The selected targets for in vitro molecular evolution techniques are four glycoside hydrolase's from the alpha-amylase super family: amylosucrase, amyl maltase, antigenic alpha-amylase and barley alpha-amylase, which share an identical active site architecture. These improved enzymes will allow the efficient transformation of European renewable agro-resources, starch and sucrose, into highly added-value products of interest for the fields of food and beverages, nutrition and health applications. The project thus conciliates both basic scientific targets; at the level of an improved understanding of glycoside hydrolyse mechanism, and very applied targets, aimed at developing new industrial environmental-friendly bio catalytic processes.

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