TELASTAR - Towards the maintenance of tissue elasticity for healthy ageing (TELASTAR) (LIFE QUALITY) (2002-01-01 - 2004-12-31) (»add to infobox)

Christian BRECHOT, Annie LECHEVALLIER, Veronique DEBISSCHOP, Christian BRECHOT, Lorenzo MORETTA, Giulio AURIEMMA, Gian Carlo PELLACANI, Domitien DEBOUZIE, Neil FERGUSON, Pierre ESPINASSE

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR101 - Paris) (France), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR101 - Paris) (France), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR716 - Rhône) (France), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR612 - Gironde) (France), ISTITUTO GIANNINA GASLINI (ITC33 - Genova) (Italy), UNIVERSITA DEGLI STUDI DELLA BASILICATA (ITF51 - Potenza) (Italy), UNIVERSITA' DI MODENA E REGGIO EMILIA (IT404 - Modena) (Italy), UNIVERSITE CLAUDE BERNARD LYON 1 (FR716 - Rhône) (France), UNIVERSITY OF MANCHESTER (UK820 - Greater Manchester) (Great Britain), UNIVERSITY OF OXFORD (UK523 - Oxfordshire) (Great Britain)

Age-related changes in elastic tissues (blood vessels, skin, lungs) lead to deterioration of elastic fibres, increased susceptibility to specific age-related diseases, and impaired repair processes. The objectives of this proposal are toa) characterize the mechanisms leading to disorganisation of human elastic tissues in ageing, b) develop strategies which control the elastic fibre neosynthesis and assembly, c) establish how their degradation might be prevented, using a synergic approach involving human pathologists, animal and cell biologists, geneticists, biochemists and biophysicists. The expected results are the control of elastic fibre assembly and remodelling, to maintain healthy conditions in ageing tissues and to treat many age-related disorders or poor repair processes, through the selective inhibition of elastic fibber degradation and/or activation of key steps in elastic fibber neosynthesis.

PERSONS (10/10)

RELATED NAVIGATION AREA(S) (2/2)