PHIL - Magnetic resonance imaging using hyperpolarized helium gas as a tool for the diagnosis of selected respiratory diseases (LIFE QUALITY) (2000-12-01 - 2004-05-31) (»add to infobox)

Etienne GUYON, Pierre DOUCELANCE, Raymond DUVAL, Jannik HILSTED, Maria NOWAKOWSKA, Karl Peter Christian SPATH, Augustin-Gregorio ZAPATA GONZALES, Marc DECHAVANNE, Gilbert BEREZIAT, Ian MCCORMICK

ECOLE NORMALE SUPERIEURE (FR101 - Paris) (France), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR101 - Paris) (France), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR107 - Val-de-Marne) (France), HVIDOVRE UNIVERSITY HOSPITAL OF COPENHAGEN (DK001 - København og Frederiksberg kommuner) (Denmark), JAGIELLONIAN UNIVERSITY (PL211 - Krakowsko-tarnowski) (Poland), JOHANNES GUTENBERG UNIVERSITAET MAINZ (DEB35 - Mainz, Kreisfreie Stadt) (Germany), UNIVERSIDAD COMPLUTENSE DE MADRID (ES300 - Madrid) (Spain), UNIVERSITE CLAUDE BERNARD LYON 1 (FR716 - Rhône) (France), UNIVERSITE PIERRE ET MARIE CURIE (FR101 - Paris) (France), UNIVERSITY OF SHEFFIELD (UK230 - South Yorkshire) (Great Britain)

Chronic Obstructive Pulmonary Diseases, including chronic bronchitis and emphysema, are of growing importance in Europe due to industrial influences, increasingly aged population and smoking habits. They can only be detected by conventional tests when already very pronounced. The project aims at validating a new non invasive method for early diagnosis, differentiation and staging of COPD: Magnetic Resonance Imaging using inhaled hyperpolarized helium 3 gas, which provides 3D anatomical images of excellent resolution, data on the dynamical function of ventilation and on airspace sizes. 9 partners from 6 countries will carry out a clinical study (150 patients, 50 volunteers), work on animal models (2 types of emphysema) and improve the methodology (production of gas, MRI techniques). The perspectives are transfer to clinics and industrial exploitation, contrast agents and drug companies, MR manufacturers).

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