MATRIX GRAFTS - Cellular production of human recombinant collagens, gelatins, laminins and growth factors and their use in vascular grafts and other applications (LIFE QUALITY) (2001-01-01 - 2004-06-30) (»add to infobox)

Hannu PIETILA, Veronique DEBISSCHOP, Juha A. KOIVURINTA, Katarina BJELKE, Dieter OESTERHELT, Raija SOLLAMO

OULUN YLIOPISTO (FI1A2 - Pohjois-Pohjanmaa) (Finland), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR716 - Rhône) (France), FIBROGEN EUROPE OYJ (FI151 - Pohjois-Pohjanmaa) (Finland), KAROLINSKA INSTITUTET (SE010 - Stockholms län) (Sweden), MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV (DE21H - München, Landkreis) (Germany), UNIVERSITY OF HELSINKI (FI110 - Uusimaa) (Finland)

Collagens and laminas have crucial roles in the extra cellular matrix. Collagens have many applications in medicine, cosmetics and commodity products. Collagens presently used for such applications are derived from animal tissues. We will develop efficient recombinant production applicable to any given collagen type, and test the efficacy of the produced human collagens in several applications. We will also develop man-made basement membranes composed of suitable combinations of collagens; laminas and growth regulators endogenously present in these therapeutically important specialized matrices, and test their use in improving the endothelialization of vascular grafts. Furthermore, we will develop recombinant production of gelatine used in numerous applications.

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